The functions of RNAs extend beyond their traditional role in protein synthesis to encompass a wide range of biological activities. RNAs regulate gene expression, modify other RNAs, and form functional complexes through interactions with proteins and metabolites. Because RNAs often fold into 3D structures to perform their functions, understanding the relationship between RNA structure and function is crucial for assessing their impact on human health and disease. Our fabulous and dedicated research team focuses on uncovering the structures and functions of RNAs involved in fundamental virological processes (viral genome replication and translation) and on exploring their potential for developing RNA-targeted therapeutics to combat genetic and infectious diseases. We combine classical and modern biochemical and biophysical methods to conduct our research, providing students and trainees with a unique opportunity to learn various techniques while contributing to cutting-edge research at the intersection of biochemistry, biophysics, and biology. Our current research centers on the RNA structures associated with genome translation and replication in (+) strand RNA viruses. Our current studies use enteroviruses as model systems and employ X-ray crystallography and a range of biochemical, biophysical, and molecular biology methods.