Welcome to the Koirala Lab!

The functions of RNAs extend beyond their traditional role in protein synthesis to encompass a wide range of biological activities. RNAs regulate gene expression, modify other RNAs, and form functional complexes through interactions with proteins and metabolites. As RNAs often fold into 3-dimensional structures to perform their functions, understanding the relationship between RNA structures and functions is crucial for comprehending its impact on human health and diseases. Our dedicated research team is focused on uncovering the structures and functions of RNAs involved in fundamental biological processes and exploring their potential for developing RNA-targeted therapeutics to combat genetic and infectious diseases. We combine classical and modern biochemical and biophysical methods, providing our team members with a unique opportunity to learn various techniques while contributing to cutting-edge research at the intersection of biochemistry, biophysics, and biology. Our current research centers on the RNA structures associated with genome translation and replication in (+)-strand RNA viruses. We use enteroviruses as our model systems and employ X-ray crystallography and various biochemical, biophysical, and molecular biology methods for our studies.